For Unitary Patents, the UPC is the only venue for litigation concerning infringement and invalidity.
For European patents in a UPC contracting state, during a transitional period, the UPC is a possible venue (alongside national courts) for infringement and validity litigation unless the patent has been opted out of the UPC by the patentee. The transitional period will last until 1 June 2030 (seven years after the commencement of the UPC) with the possibility that it will be extended for up to a further seven years.
For national patents, national courts remain the only venue for litigation. However recent case law of the UPC is showing that the UPC is happy to rule on infringement and validity in non-UPC contracting states, including those EPC states not in the EU (e.g. UK).